NEWS

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BioTransition 2.0.0

New Features

• Added tDNB() function implementing topological DNB analysis using scale-free network topology
• Implemented C++ acceleration for correlation analysis and module scoring via Rcpp (2-20x speedup)
• Added built-in protein-protein interaction networks for human (ppi_h) and mouse (ppi_m) from STRING database
• New helper functions: fast_cor_cpp(), fast_cor_pval_cpp(), fast_module_score_cpp(), fast_bh_adjust()

Improvements

• Unified API across all seven DNB methods
• Enhanced documentation with comprehensive vignette
• Added support for single-cell RNA-seq and spatial transcriptomics data
• Improved memory efficiency for large-scale datasets

Bug Fixes

• Fixed correlation calculation for samples with zero variance
• Resolved edge cases in module detection with small sample sizes

BioTransition 1.0.0

Initial Release

• Implemented six DNB methods: cDNB, LcDNB, LDNB, MDNB, TSNMB, TSLE
• Support for bulk RNA-seq data analysis
• Basic documentation and examples