Changes in version 2.0.0 New Features - Added tDNB() function implementing topological DNB analysis using scale-free network topology - Implemented C++ acceleration for correlation analysis and module scoring via Rcpp (2-20x speedup) - Added built-in protein-protein interaction networks for human (ppi_h) and mouse (ppi_m) from STRING database - New helper functions: fast_cor_cpp(), fast_cor_pval_cpp(), fast_module_score_cpp(), fast_bh_adjust() Improvements - Unified API across all seven DNB methods - Enhanced documentation with comprehensive vignette - Added support for single-cell RNA-seq and spatial transcriptomics data - Improved memory efficiency for large-scale datasets Bug Fixes - Fixed correlation calculation for samples with zero variance - Resolved edge cases in module detection with small sample sizes Changes in version 1.0.0 Initial Release - Implemented six DNB methods: cDNB, LcDNB, LDNB, MDNB, TSNMB, TSLE - Support for bulk RNA-seq data analysis - Basic documentation and examples