Package: scFOCAL Type: Package Title: Integration of Drug and Single-Cell Gene Expression Signatures Version: 0.1.0 Authors@R: c( person("Zaoqu", "Liu", email = "liuzaoqu@163.com", role = c("aut", "cre"), comment = c(ORCID = "0000-0002-0452-742X")), person("Robert K.", "Suter", email = "rks82@georgetown.edu", role = "aut"), person("Nagi G.", "Ayad", email = "na853@georgetown.edu", role = "aut") ) Author: Zaoqu Liu [aut, cre] (), Robert K. Suter [aut], Nagi G. Ayad [aut] Maintainer: Zaoqu Liu Description: scFOCAL integrates small molecules transcriptional consensus signatures with single-cell gene expression data to identify cell states targeted or resistant to different perturbations. This information is leveraged by the scFOCAL combination index, which identifies synergistic combinations that maximize the discordance across a heterogenous tumor. License: file LICENSE Encoding: UTF-8 LazyData: true RoxygenNote: 7.3.2 URL: https://github.com/Zaoqu-Liu/scFOCAL BugReports: https://github.com/Zaoqu-Liu/scFOCAL/issues Depends: R (>= 3.5) Imports: ComplexHeatmap, corrplot, cowplot, DT, dplyr, edgeR, EnhancedVolcano, fields, ggalluvial, ggforce, ggplot2, ggpubr, ggrepel, ggsci, grid, Hmisc, htmlwidgets, lme4, MASS, MAST, pheatmap, plotly, reshape2, scales, shiny, shinydashboard, shinythemes, stats, stringr, tibble, tidyr, viridis Suggests: Seurat (>= 4.0.0), SeuratObject (>= 4.0.0), testthat (>= 3.0.0), knitr, rmarkdown, gridExtra, circlize, RColorBrewer VignetteBuilder: knitr Config/testthat/edition: 3 Config/pak/sysreqs: cmake libfontconfig1-dev libfreetype6-dev make libicu-dev libpng-dev libuv1-dev libssl-dev perl zlib1g-dev Repository: https://zaoqu-liu.r-universe.dev Date/Publication: 2026-02-03 08:28:54 UTC RemoteUrl: https://github.com/Zaoqu-Liu/scFOCAL RemoteRef: main RemoteSha: fb312da4176dc1d3a58f9371f5e73fd96e6ca0b3 NeedsCompilation: no Packaged: 2026-07-03 09:22:39 UTC; root