Package: scMetaLink
Type: Package
Title: Single-Cell Metabolite-Mediated Cell Communication Analysis
Version: 0.99.1
Date: 2026-01-26
Authors@R: person("Zaoqu", "Liu", email = "liuzaoqu@163.com", role = c("aut", "cre"), 
                  comment = c(ORCID = "0000-0002-0452-742X"))
Author: Zaoqu Liu [aut, cre] (<https://orcid.org/0000-0002-0452-742X>)
Maintainer: Zaoqu Liu <liuzaoqu@163.com>
Description: A comprehensive framework for inferring
        metabolite-mediated cell-cell communication from single-cell
        transcriptomic data. scMetaLink integrates metabolite
        production potential via enzyme expression, metabolite sensing
        capability via receptor and transporter expression, and
        secretion potential to construct intercellular metabolic
        communication networks. The package leverages the MetalinksDB
        database containing 41894 metabolite-protein interactions
        covering 1128 metabolites and 4374 proteins. Key features
        include probabilistic inference of metabolite production,
        receptor-mediated metabolite sensing quantification,
        permutation-based statistical testing with multiple hypothesis
        correction, pathway-level aggregation analysis, and
        publication-ready visualization.
License: MIT + file LICENSE
Encoding: UTF-8
LazyData: true
LazyDataCompression: xz
Depends: R (>= 4.0.0)
Imports: methods, stats, utils, grDevices, graphics, Matrix, ggplot2,
        ggraph, igraph, scales, circlize, ComplexHeatmap, grid,
        viridis, RColorBrewer, future, future.apply
Suggests: Seurat (>= 4.0.0), SingleCellExperiment,
        SummarizedExperiment, testthat (>= 3.0.0), knitr, rmarkdown,
        BiocStyle, reshape2, pkgdown
VignetteBuilder: knitr
biocViews: Software, SingleCell, Transcriptomics, CellBiology,
        Metabolomics, Network, Visualization, GeneExpression, Spatial
RoxygenNote: 7.3.3
Config/testthat/edition: 3
URL: https://github.com/Zaoqu-Liu/scMetaLink,
        https://Zaoqu-Liu.github.io/scMetaLink/
BugReports: https://github.com/Zaoqu-Liu/scMetaLink/issues
Config/pak/sysreqs: libfontconfig1-dev libfreetype6-dev libglpk-dev
        libicu-dev libpng-dev libxml2-dev perl
Repository: https://zaoqu-liu.r-universe.dev
Date/Publication: 2026-01-26 15:42:34 UTC
RemoteUrl: https://github.com/Zaoqu-Liu/scMetaLink
RemoteRef: HEAD
RemoteSha: d5e03bd61e72741e7fce77da7980a68261c230e3
NeedsCompilation: no
Packaged: 2026-05-28 10:55:23 UTC; root