Package: scaper 0.2.1

scaper: Single Cell Transcriptomics-Level Cytokine Activity Prediction and Estimation

Generates cell-level cytokine activity estimates using relevant information from gene sets constructed with the 'CytoSig' and the 'Reactome' databases and scored using the modified 'Variance-adjusted Mahalanobis (VAM)' framework for single-cell RNA-sequencing (scRNA-seq) data. 'CytoSig' database is described in: Jiang at al., (2021) <doi:10.1038/s41592-021-01274-5>. 'Reactome' database is described in: Gillespie et al., (2021) <doi:10.1093/nar/gkab1028>. The 'VAM' method is outlined in: Frost (2020) <doi:10.1093/nar/gkaa582>.

Authors:Zaoqu Liu [aut, cre], H. Robert Frost [aut], Azka Javaid [aut]

scaper_0.2.1.tar.gz
scaper_0.2.1.zip(r-4.7)scaper_0.2.1.zip(r-4.6)scaper_0.2.1.zip(r-4.5)
scaper_0.2.1.tgz(r-4.6-any)scaper_0.2.1.tgz(r-4.5-any)
scaper_0.2.1.tar.gz(r-4.7-any)scaper_0.2.1.tar.gz(r-4.6-any)
scaper_0.2.1.tgz(r-4.6-emscripten)
manual.pdf |manual.html
DESCRIPTION |NEWS
card.svg |card.png
scaper/json (API)

# Install 'scaper' in R:
install.packages('scaper', repos = c('https://zaoqu-liu.r-universe.dev', 'https://cloud.r-project.org'))

Bug tracker:https://github.com/zaoqu-liu/scaper/issues

On CRAN:

Conda:

3.54 score 14 scripts 551 downloads 6 exports 143 dependencies

Last updated from:76fae1d8a4 (on main). Checks:9 OK. Indexed: no.

TargetResultTimeFilesSyslog
linux-devel-x86_64OK255
source / vignettesOK255
linux-release-x86_64OK240
macos-release-arm64OK137
macos-oldrel-arm64OK139
windows-develOK178
windows-releaseOK175
windows-oldrelOK194
wasm-releaseOK205

Exports:%>%genesetCytoSiggenesetReactomescapescapeForSeuratsupportedCytokines

Dependencies:abindaskpassbase64encBHbitopsbslibcachemcaToolscliclustercodetoolscommonmarkcowplotcpp11crosstalkcurldata.tabledeldirdigestdotCall64dplyrdqrngevaluatefarverfastDummiesfastmapfitdistrplusFNNfontawesomefsfuturefuture.applygenericsggplot2ggrepelggridgesglobalsgluegoftestgplotsgridExtragtablegtoolsherehighrhtmltoolshtmlwidgetshttpuvhttricaigraphirlbaisobandjquerylibjsonliteKernSmoothknitrlabelinglaterlatticelazyevallifecyclelistenvlmtestmagrittrMASSMatrixmatrixStatsmemoisemimeminiUInlmeopensslotelparallellypatchworkpbapplypillarpkgconfigplotlyplyrpngpolyclipprogressrpromisespurrrR6RANNrappdirsRColorBrewerRcppRcppAnnoyRcppArmadilloRcppEigenRcppHNSWRcppProgressRcppTOMLreshape2reticulaterlangrmarkdownROCRrprojrootRSpectraRtsneS7sassscalesscattermoresctransformSeuratSeuratObjectshinysitmosourcetoolsspspamspatstat.dataspatstat.explorespatstat.geomspatstat.randomspatstat.sparsespatstat.univarspatstat.utilsstringistringrsurvivalsystensortibbletidyrtidyselecttinytexutf8uwotvctrsviridisLitewithrxfunxml2xtableyamlzoo

Algorithm Details: Mathematical Foundation of scaper
Introduction | Mathematical Formulation | Variance-Adjusted Mahalanobis (VAM) Distance | CDF Transformation | Bidirectional Scoring (CytoSig) | Gene Set Information | CytoSig Database | Weight Distribution | Reactome Database | Score Interpretation | References | Session Information

Last update: 2026-01-25
Started: 2026-01-25

Introduction to scaper: Cytokine Activity Estimation in Single Cells
Overview | Key Features | Installation | Supported Cytokines | CytoSig Database (n = 41) | Reactome Database (n = 30) | Quick Start | Basic Usage with Seurat | Basic Usage with Matrix | Gene Set Construction | CytoSig Gene Set Example | Reactome Gene Set Example | Score Interpretation | Session Information

Last update: 2026-01-25
Started: 2026-01-25

Cytokine Activity Estimation using SCAPE (Single cell transcriptomics-level Cytokine Activity Prediction and Estimation): An Analysis using the CytoSig database.

Last update: 2026-01-25
Started: 2026-01-25

Cytokine Activity Estimation using SCAPE (Single cell transcriptomics-level Cytokine Activity Prediction and Estimation): An Analysis using the Reactome database.

Last update: 2026-01-25
Started: 2026-01-25

Visualization Guide for scaper
Introduction | Basic Heatmap | Seurat Integration | Distribution Analysis | Correlation Analysis | Best Practices | Session Information

Last update: 2026-01-25
Started: 2026-01-25